Allergen-specific immunotherapy induces regulatory T cells in an atopic dermatitis mouse model.
Jung U ShinS H KimJ Y NohJ H KimH R KimK Y JeongKyung Hee ParkJ LeeH ChuJ-H LeeT-S YongJ-W ParkK H LeePublished in: Allergy (2018)
We established a SIT model on AD mice and showed that our model correlates well with previous reports about SIT-treated patients. Also, we revealed NK cells as another possible resource of IL-10 in SIT. Based on our results, we suggest our SIT model as a useful tool to investigate mechanism of action of SIT and to validate the efficacy of new SIT modalities for the treatment of AD.
Keyphrases
- regulatory t cells
- mouse model
- end stage renal disease
- newly diagnosed
- atopic dermatitis
- nk cells
- dendritic cells
- ejection fraction
- chronic kidney disease
- prognostic factors
- emergency department
- metabolic syndrome
- peritoneal dialysis
- skeletal muscle
- adipose tissue
- insulin resistance
- replacement therapy
- combination therapy
- high fat diet induced
- patient reported
- electronic health record
- smoking cessation