Genetically engineered E. coli Nissle attenuates hyperammonemia and prevents memory impairment in bile-duct ligated rats.
Rafael Ochoa-SanchezMariana M OliveiraMélanie TremblayGrégory PetrazzoAsha PantCristina R BosoiMylene PerreaultWilliam QuerbesCaroline B KurtzChristopher F RosePublished in: Liver international : official journal of the International Association for the Study of the Liver (2021)
S-ARG and S-ARG + BUT attenuated hyperammonemia, with S-ARG + BUT additional memory protection likely due to greater anti-inflammatory effect. These innovative strategies, particularly S-ARG + BUT, have potential to prevent HE.