Sensitive silica-alumina modified capacitive non-Faradaic glucose sensor for gestational diabetes.
Lizhen ChenWenyang XieYao LuoXiaolan DingBing FuSubash C B GopinathYuanhuan XiongPublished in: Biotechnology and applied biochemistry (2021)
A highly sensitive silica-alumina (Si-Al)-modified capacitive non-Faradaic glucose biosensor was introduced to monitor gestational diabetes. Glucose oxidase (GOx) was attached to the Si-Al electrode surface as the probe through amine-modification followed by glutaraldehyde premixed GOx as aldehyde-amine chemistry. This Si-Al (∼50 nm) modified electrode surface has increased the current flow upon binding of GOx with glucose. Capacitance values were increased by increasing the glucose concentrations. A mean capacitance value was plotted and the detection limit was found as 0.03 mg/mL with the regression coefficient value, R² = 0.9782 [y = 0.8391x + 1.338] on the linear range between 0.03 and 1 mg/mL. Further, a biofouling experiment with fructose and galactose did not increase the capacitance, indicating the specific glucose detection. This Si-Al-modified capacitance sensor detects a lower level of glucose presence and helps in monitoring gestational diabetes.
Keyphrases
- blood glucose
- room temperature
- type diabetes
- gold nanoparticles
- magnetic resonance imaging
- label free
- blood pressure
- magnetic resonance
- loop mediated isothermal amplification
- photodynamic therapy
- insulin resistance
- sensitive detection
- high resolution
- skeletal muscle
- carbon nanotubes
- fluorescent probe
- molecularly imprinted
- drug discovery
- diffusion weighted imaging
- binding protein
- real time pcr