Low cost automated whole smear microscopy screening system for detection of acid fast bacilli.
Yan Nei LawHanbin JianNorman W S LoMargaret IpMia Mei Yuk ChanJoseph Km KamXiaohua WuPublished in: PloS one (2018)
Our system achieved high sensitivity without substantially compromising specificity when compared to culture results. Significant improvement in specificity was obtained when uncertain results were confirmed by manual smear grading. This approach had potential to substantially reduce workload of microscopists in high burden countries.
Keyphrases
- low cost
- pulmonary tuberculosis
- label free
- high throughput
- structural basis
- gram negative
- single molecule
- high resolution
- machine learning
- mycobacterium tuberculosis
- deep learning
- loop mediated isothermal amplification
- high speed
- optical coherence tomography
- risk factors
- real time pcr
- human health
- multidrug resistant
- mass spectrometry