Complex association patterns for inflammatory mediators in induced sputum from subjects with asthma.
Annette T HastieC SteeleC W DunawayW C MooreB M RectorE AmplefordH LiL C DenlingerN JarjourD A MeyersE R Bleeckernull nullPublished in: Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology (2018)
Sputum cytokines, chemokines and growth factors were increased in severe asthma, primarily with increased neutrophils. Factor analysis identified complex inflammatory protein interactions, suggesting airway inflammation in asthma is characterized by overlapping immune pathways. Thus, focus on a single specific inflammatory mediator or pathway may limit understanding the complexity of inflammation underlying airway changes in asthma and selection of appropriate therapy.