Six-Month Outcomes after Restrictive or Liberal Transfusion for Cardiac Surgery.
C David MazerRichard P WhitlockDean A FergussonEmilie Belley-CoteKatherine ConnollyBoris KhanykinAlexander J GregoryÉtienne de MédicisFrançois-Martin CarrierShay McGuinnessPaul J YoungKelly ByrneJuan C VillarAlistair G RoyseHilary P GrocottManfred D SeebergerChirag MehtaFrançois LelloucheGregory M T HareThomas W PainterStephen FremesSummer SyedSean M BagshawNian-Chih HwangColin RoyseJudith HallDavid DaiNikhil MistryKevin ThorpeSubodh VermaPeter JüniNadine Shehatanull nullPublished in: The New England journal of medicine (2018)
In patients undergoing cardiac surgery who were at moderate-to-high risk for death, a restrictive strategy for red-cell transfusion was noninferior to a liberal strategy with respect to the composite outcome of death from any cause, myocardial infarction, stroke, or new-onset renal failure with dialysis at 6 months after surgery. (Funded by the Canadian Institutes of Health Research and others; TRICS III ClinicalTrials.gov number, NCT02042898 .).