Cerebral blood flow, amyloid burden, and cognition in cognitively normal individuals.
Jarith L EbenauDenise VisserSander C J VerfaillieTessa TimmersMardou S S A van LeeuwenstijnMara Ten KateAlbert D WindhorstFrederik BarkhofPhilip ScheltensNiels D PrinsRonald BoellaardWiesje M van der FlierBart N M van BerckelPublished in: European journal of nuclear medicine and molecular imaging (2022)
Our results suggest that amyloid accumulation and decrease in rCBF are two parallel disease processes without a fixed order, both providing unique predictive information for cognitive decline and each process enhancing the other longitudinally.