Osteogenic differentiation in dedifferentiated liposarcoma: a study of 36 cases in comparison to the cases without ossification.

Kyoko YamashitaKenichi KohashiYuichi YamadaTakeaki IshiiYoshihiro NishidaHiroshi UrakawaIchiro ItoMitsuru TakahashiTakeshi InoueMasafumi ItoYuuki OharaYoshinao OdaShinya Toyokuni

Published in: Histopathology (2017)

The bone tissue formed in DDLPS was mainly neoplastic regardless of its morphology and maturity, which highlighted the osteogenic differentiation of the tumour cells. DDLPS patients with osteogenic differentiation tended to suffer from earlier local recurrences, which did not necessarily lead to poor life outcomes.

Keyphrases

mesenchymal stem cells
bone marrow
induced apoptosis
cell cycle arrest
bone mineral density
type diabetes
oxidative stress
cell death
adipose tissue
bone regeneration
skeletal muscle
metabolic syndrome
bone loss
insulin resistance
glycemic control
clinical evaluation