Use of patient-derived explants as a preclinical model for precision medicine in colorectal cancer: A scoping review.

Milton MuiMolly ClarkTamara M S H VuNicholas ClemonsFrédéric HollandeSara RothRobert RamsayMichael MichaelAlexander G HeriotJoseph C H Kong

Published in: Langenbeck's archives of surgery (2023)

Given the preservation of tumour microenvironment and tumour heterogeneity, patient-derived explants has the potential to identify reliable biomarkers, treatment resistance mechanisms, and novel therapeutic agents. Further validation studies are required to characterise, refine and standardise this preclinical model before it can become a part of precision medicine in colorectal cancer.

Keyphrases

cell therapy
stem cells
single cell
mesenchymal stem cells
combination therapy
climate change
case control