Renal Klotho safeguards platelet lifespan in advanced chronic kidney disease through restraining Bcl-xL ubiquitination and degradation.

Qigang Lan Changhong Du Jiachuan Xiong Yiding Wu Weinian Liao Chaonan Liu Jun Chen Li Ran Yue Wang Yaqin Wang Jun-Ping Wang Jinghong Zhao Ke Yang

Published in: Journal of thrombosis and haemostasis : JTH (2022)

Our findings uncover the mechanism of platelet count decline in Adv-CKD and identify renal Klotho as a long-range regulator of platelet lifespan, which not only provide a molecular mechanism underlying CKD-associated thrombocytopenia and hemorrhage but also offer a promising therapy choice.

Keyphrases

chronic kidney disease
end stage renal disease
transcription factor
mesenchymal stem cells
smoking cessation