Detection of recombinant Spike protein in the blood of individuals vaccinated against SARS-CoV-2: Possible molecular mechanisms.

Carlo BrognaSimone CristoniGiuliano MarinoLuigi MontanoValentina VidutoMark FabrowskiGennaro LettieriMarina Piscopo

Published in: Proteomics. Clinical applications (2023)

The presented method allows to evaluate the half-life of the Spike protein molecule "PP" and to consider the risks or benefits in continuing to administer additional booster doses of the SARS-CoV-2 mRNA vaccine. This approach is of valuable support to complement antibody level monitoring and represents the first proteomic detection of recombinant Spike in vaccinated subjects.

Keyphrases

sars cov
label free
respiratory syndrome coronavirus
loop mediated isothermal amplification
binding protein
protein protein
real time pcr
amino acid
human health
small molecule
risk assessment
coronavirus disease
climate change
sensitive detection