Molecular Genetics and the Role of Molecularly Targeted Agents in Metastatic Colorectal Carcinoma.

Ahmed NaeemAung Myint TunElizabeth Guevara

Published in: Journal of gastrointestinal cancer (2021)

Alterations in several oncogenes are associated with CRC, among those RAS, BRAF, and HER2 are of current clinical importance. Chemotherapy drugs, along with vascular endothelial growth factor or epidermal growth factor receptor monoclonal antibodies, are proven to be efficient with manageable toxicity profiles in metastatic CRC. Additional researches on Her-2-directed therapy, BRAF-targeted agents, immunotherapeutic, and newer molecularly targeted agents are needed for further improvement in outcome.

Keyphrases

epidermal growth factor receptor
vascular endothelial growth factor
cancer therapy
small cell lung cancer
squamous cell carcinoma
wild type
tyrosine kinase
advanced non small cell lung cancer
oxidative stress
endothelial cells
drug delivery
single molecule
drug induced
chemotherapy induced