Molecular clustering of genes related to the atopic syndrome: Towards a more tailored approach and personalized medicine?

Jill de WitRogier T A van WijckVirgil A S H DalmKristen L SnyderJoan E E TottéSuzanne G M A PasmansPeter J van der Speknull null

Published in: Clinical and translational allergy (2019)

This study shows a model to define clusters within the atopic syndrome based on gene expression profiles of immune cell lineages. Our results support the hypothesis that both genetic mechanisms and immune dysregulation play a role in the pathogenesis. It also opens up the possibility for novel therapeutic targets and a more tailored approach towards personalized medicine.

Keyphrases

genome wide
copy number
case report
smoking cessation
genome wide identification
dna methylation
single cell
rna seq
genome wide analysis