Oral Cytokine Levels Are More Linked to Levels of Plasma and Oral HIV-1 RNA Than to CD4+ T-Cell Counts in People With HIV.
Joseph M RoccoZachary YorkChengli ShenCaroline ShiboskiJennifer Cyriaque-WebsterJanet McLaughlinLuann BorowskiHuichao ChenJudith A AbergDirk P DittmerMahmoud GhannoumCharles R RinaldoBernard MacatangayPublished in: Open forum infectious diseases (2020)
Our results show that high levels of oral HIV-1, rather than low CD4 counts, were linked to the production of oral immune mediators. Participants with AIDS and uncontrolled viremia demonstrated higher levels of pro- and anti-inflammatory soluble immune mediators compared with participants with lower HIV-1 RNA. The interplay of HIV-1 and these immune mediators could be important in the oral health of PWH.