Antioxidative myricetin-enriched nanoparticles towards acute liver injury.
Tianyou WangJianhua ZhangHengjie ZhangWanjie BaiJinhong DongZhen YangPeng YangZhipeng GuYiwen LiXianchun ChenYuanting XuPublished in: Journal of materials chemistry. B (2022)
Acute liver injury (ALI) could severely destroy the liver function and cause inevitable damage to human health. Studies have demonstrated that excessive reactive oxygen species (ROS) and accompanying inflammatory factors play vital roles in the ALI disease. Herein, we fabricated a kind of nature-inspired myricetin-enriched nanomaterial via Michael addition and Schiff base reaction, which possessed uniform morphology, tunable component ratios, great stabilities, promising free radical scavenging abilities, biocompatibility and protective effects towards cells under oxidative stress. Additionally, the therapeutic effects were demonstrated using an ALI model by down-regulating ROS and inflammatory levels and restoring the liver function. This study could provide a strategy to construct robust and antioxidative nanomaterials using naturally occurring molecules against intractable diseases.
Keyphrases
- liver injury
- drug induced
- oxidative stress
- reactive oxygen species
- human health
- induced apoptosis
- dna damage
- risk assessment
- cell death
- ischemia reperfusion injury
- cell cycle arrest
- liver failure
- anti inflammatory
- climate change
- diabetic rats
- respiratory failure
- endoplasmic reticulum stress
- weight gain
- intensive care unit
- signaling pathway
- cell proliferation
- acute respiratory distress syndrome
- quantum dots
- energy transfer
- heat stress
- tissue engineering