A novel protein FNDC3B-267aa encoded by circ0003692 inhibits gastric cancer metastasis via promoting proteasomal degradation of c-Myc.

Yu-Ying LiuYu-Ying ZhangLing-Yu RanBo HuangJun-Wu RenQiang MaXiao-Juan PanFei-Fei YangCe LiangXiao-Lin WangShi-Min WangAi RanHao NingYan JiangChang-Hong QinBin Xiao

Published in: Journal of translational medicine (2024)

Our study revealed that the novel protein FNDC3B-267aa encoded by circ0003692 suppressed GC metastasis through binding to c-Myc and enhancing proteasome-mediated degradation of c-Myc. The study offers the potential applications of circ0003692 or FNDC3B-267aa as therapeutic targets for GC.

Keyphrases

single cell
amino acid
high resolution
human health