Tailoring Adjuvant Chemotherapy to Biologic Response Following Neoadjuvant Chemotherapy Impacts Overall Survival in Pancreatic Cancer.
Elie M GhabiSami ShoucairDing DingAmmar A JavedElizabeth D ThompsonLei ZhengJohn L CameronChristopher L WolfgangChristopher R ShubertKelly J LafaroRichard A BurkhartWilliam R BurnsJin HePublished in: Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract (2022)
CA19-9 normalization in response to NAT was associated with favorable outcomes and can serve as a biomarker for treatment response. In patients where CA19-9 did not normalize, receipt of postoperative chemotherapy was associated with improved OS. These patients also benefited from additional 5FU-based postoperative chemotherapy following 5FU-based NAT.