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Ribosome Specialization in Protozoa Parasites.

Cristian Camilo Rodríguez-AlmonacidMorgana K KelloggAndrey L KaramyshevZemfira N Karamysheva
Published in: International journal of molecular sciences (2023)
Ribosomes, in general, are viewed as constitutive macromolecular machines where protein synthesis takes place; however, this view has been recently challenged, supporting the hypothesis of ribosome specialization and opening a completely new field of research. Recent studies have demonstrated that ribosomes are heterogenous in their nature and can provide another layer of gene expression control by regulating translation. Heterogeneities in ribosomal RNA and ribosomal proteins that compose them favor the selective translation of different sub-pools of mRNAs and functional specialization. In recent years, the heterogeneity and specialization of ribosomes have been widely reported in different eukaryotic study models; however, few reports on this topic have been made on protozoa and even less on protozoa parasites of medical importance. This review analyzes heterogeneities of ribosomes in protozoa parasites highlighting the specialization in their functions and their importance in parasitism, in the transition between stages in their life cycle, in the change of host and in response to environmental conditions.
Keyphrases
  • life cycle
  • gene expression
  • plasmodium falciparum
  • healthcare
  • dna methylation
  • emergency department