Epigenomics and transcriptomics of systemic sclerosis CD4+ T cells reveal long-range dysregulation of key inflammatory pathways mediated by disease-associated susceptibility loci.
Tianlu LiLourdes Ortiz-FernándezEduardo Andrés-LeónLaura CiudadBiola M JavierreElena López-IsacAlfredo Guillén-Del-CastilloCarmen Pilar Simeón-AznarEsteban BallestarJavier MartinPublished in: Genome medicine (2020)
Our study unveils a potential link between genetic, epigenetic, and transcriptional deregulation in CD4+ T cells of SSc patients, providing a novel integrated view of molecular components driving SSc pathogenesis.
Keyphrases
- systemic sclerosis
- genome wide
- end stage renal disease
- interstitial lung disease
- dna methylation
- newly diagnosed
- chronic kidney disease
- ejection fraction
- single cell
- peritoneal dialysis
- oxidative stress
- prognostic factors
- transcription factor
- rheumatoid arthritis
- patient reported outcomes
- copy number
- climate change
- patient reported
- heat shock protein