Glycolytic PFKFB3 and Glycogenic UGP2 Axis Regulates Perfusion Recovery in Experimental Hind Limb Ischemia.

Olukemi JaiyesimiSivaraman KuppuswamyGuangwei ZhangSonia BatanWenbo Zhi Vijay C Ganta

Published in: Arteriosclerosis, thrombosis, and vascular biology (2024)

Our data present that inhibition of maladaptive PFKFB3-driven glycolysis in HSS-ECs is necessary to promote the UGP2-uridine diphosphate-glucose axis that enhances ischemic angiogenesis and perfusion recovery in experimental PAD.

Keyphrases

contrast enhanced
endothelial cells
magnetic resonance imaging
computed tomography
metabolic syndrome
magnetic resonance
insulin resistance
weight loss
skeletal muscle
wound healing
deep learning