Rapid Expansion of Highly Functional Antigen-Specific T Cells from Patients with Melanoma by Nanoscale Artificial Antigen-Presenting Cells.

Junya IchikawaTatsuya YoshidaAriel IsserAndressa S LainoMelinda VassalloDavid WoodsSojung KimMathias OelkeKristi JonesJonathan P SchneckJeffrey S Weber

Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2020)

Peptide-pulsed nano-aAPC rapidly expanded polyfunctional antigen-specific CD8 T cells with high avidity, potent lytic function, and a stem cell memory phenotype from patients with melanoma.

Keyphrases

stem cells
induced apoptosis
cell cycle arrest
working memory
atomic force microscopy
signaling pathway
cell death
oxidative stress
mesenchymal stem cells
cell proliferation
cell therapy
high speed