Blood Differential Gene Expression in Patients with Chronic Heart Failure and Systemic Iron Deficiency: Pathways Involved in Pathophysiology and Impact on Clinical Outcomes.

Carles Diez-LópezMarta Tajes OrduñaCristina Enjuanes GrauPedro Moliner BorjaJosé González-CostelloElena García-RomeroJosep Francesch ManzanoSergi YunSantiago Jiménez-MarreroRaul Ramos-PoloMaria Del Mar Ras JiménezJosep Comín Colet

Published in: Journal of clinical medicine (2021)

Patients with chronic heart failure present different patterns of blood gene expression depending on systemic iron status that affect pivotal genes involved in iron regulation, mitochondrial metabolism, endothelial function and cardiovascular physiology, and correlate with adverse clinical outcomes.

Keyphrases

iron deficiency
gene expression
dna methylation
ejection fraction
oxidative stress
emergency department
drug induced
adverse drug