Transplantation-Induced Ischemia-Reperfusion Injury Modulates Antigen Presentation by Donor Renal CD11c+F4/80+ Macrophages through IL-1R8 Regulation.

Sistiana AielloManuel Alfredo PodestàPamela Y Rodriguez-OrdonezFrancesca PezzutoNadia AzzolliniSamantha SoliniCamillo CarraraMarta TodeschiniFederica CasiraghiMarina Noris Guiseppe RemuzziAriela Benigni

Published in: Journal of the American Society of Nephrology : JASN (2020)

IL-1R8 is a key regulator of donor renal macrophage functions after ischemia-reperfusion injury, crucial to guiding the phenotype and antigen-presenting role of these cells. It may therefore represent an intriguing pathway to explore with respect to modulating responses against autoantigens and alloantigens after kidney transplant.

Keyphrases

ischemia reperfusion injury
oxidative stress
induced apoptosis
diabetic rats
case report
cell cycle arrest
signaling pathway
adipose tissue
transcription factor
endoplasmic reticulum stress
cell therapy
nk cells
mesenchymal stem cells