Approaches to induce the maturation process of human induced pluripotent stem cell derived-endothelial cells to generate a robust model.

Suzan de Boer Sebastiaan N J LaanRichard DirvenJeroen Eikenboom

Published in: PloS one (2024)

hiPSCs-ECs have the potential to show a more mature endothelial phenotype with elongated WPBs after >30 days in culture. However, this comes with limitations as there are very few cells detected, and cells are deteriorating after being in culture for extended periods of time.

Keyphrases

endothelial cells
induced apoptosis
high glucose
cell cycle arrest
cell death
signaling pathway
risk assessment
vascular endothelial growth factor
climate change
human health