Surgical resection combined with perioperative chemotherapy for a patient with locally recurrent, previously stage IV thymic small-cell carcinoma: A case report.
Junki TeradaYuko ToyodaEiji TakeuchiNobuyuki TanidaSatoshi ItoKenji YoritaHisashi MatsuokaHiroki BandoYutaka MoritaYuri OkamotoTsutomu ShinoharaPublished in: Thoracic cancer (2022)
An 83-year-old Japanese man visited our hospital with dyspnea and general fatigue. Computed tomography (CT) revealed a tumor in the anterior mediastinum, bilateral pleural effusion, pericardial fluid, and multiple liver nodules. We performed a CT-guided tumor biopsy, and the patient was diagnosed with thymic small-cell carcinoma, Masaoka-Koga stage classification IVb. The patient received four cycles of carboplatin and etoposide, and all lesions disappeared on CT. However, after 6 months, CT revealed a recurrent tumor in the anterior mediastinum. After one cycle of rechallenge chemotherapy, we performed extended total thymectomy followed by another three cycles of chemotherapy. More than 2.5 years after the last chemotherapy session, the patient's carcinoma did not recur. Thus, this case suggests that salvage surgery may be a treatment option for local recurrence of thymic carcinoma after complete remission with chemotherapy, even in patients with stage IV cancer.
Keyphrases
- computed tomography
- dual energy
- image quality
- case report
- locally advanced
- contrast enhanced
- positron emission tomography
- magnetic resonance imaging
- healthcare
- squamous cell carcinoma
- single cell
- rectal cancer
- rheumatoid arthritis
- coronary artery disease
- papillary thyroid
- radiation therapy
- patients undergoing
- atrial fibrillation
- cardiac surgery
- young adults
- combination therapy
- ultrasound guided
- palliative care
- depressive symptoms
- lymph node metastasis
- free survival
- fine needle aspiration