Microfluidic Fabrication of Bioinspired Cavity-Microfibers for 3D Scaffolds.

We present a gas-in-water microfluidic method to precisely fabricate well-controlled versatile microfibers with cavity knots (named cavity-microfiber), like tiny-cavity-microfiber, hybrid-cavity-microfiber, cavity-microfiber, and chained microfiber. The cavity-microfibers are endowed with tunable morphologies, unique surface properties, high specific surface area, assembling ability, flexibility, cytocompatibility, and hydroscopicity. We assemble cavity-microfibers as 3D scaffolds for culturing the human umbilical vein endothelial cells (HUVECs) and dehumidifying. The HUVECs on the scaffolds demonstrate good cell viability and 3D HUVECs frameworks, confirming the unique cytocompatibility of cavity-microfiber. And the cavity-microfibers and their scaffolds also demonstrate excellent dehumidifying ability and large-scale dehumidifying, respectively. Our cavity-microfiber can offer a broad range of applications in sensor, wearable electronics, dehumidifying, water collection engineering, drug delivery, biomaterials, and tissue engineering.