Chordoma dedifferentiation after proton beam therapy: a case report and review of the literature.
Joseph A FranklCassi GrotepasBaldassare SteaG Michael LemoleAlexander ChiuRihan KhanPublished in: Journal of medical case reports (2016)
The short time period between radiation therapy and dedifferentiation, low dose of photons, and rarity of dedifferentiated skull base chordomas in pediatric patients should alert clinicians to the possibility of chordoma dedifferentiation after proton beam therapy.