Sesquiterpenoids from Ixeris sonchifolia and their neuroprotective activities.
Yan YuanZhuo-Fan HuFeng-Li WangLuo-Sheng WanYing GongJia-Chun ChenPublished in: Journal of Asian natural products research (2021)
The phytochemical investigation of the methanol extract of Ixeris sonchifolia led to the isolation and identification of nine analogs, including one new guaiane-type sesquiterpenoid, named ixerinoid A ( 1 ). The structure of 1 was determined by extensive analysis of the 1 D and 2 D nuclear magnetic resonance spectroscopic data, as well as quantum chemical calculations. Additionally, all the isolates were tested for their neuroprotective activity using the oxygen-glucose deprivation/reperfusion-induced SH-SY5Y cell injury model. Compounds 3 , 5 , 6 , 8 , and 9 displayed remarkable protective effects at concentrations of 1, 5, and 10 μ M, respectively.
Keyphrases
- cerebral ischemia
- magnetic resonance
- molecular docking
- molecular dynamics
- subarachnoid hemorrhage
- blood brain barrier
- brain injury
- high glucose
- molecular dynamics simulations
- diabetic rats
- single cell
- oxidative stress
- density functional theory
- monte carlo
- electronic health record
- acute myocardial infarction
- big data
- blood glucose
- drug induced
- contrast enhanced
- carbon dioxide
- endothelial cells
- stem cells
- type diabetes
- coronary artery disease
- heart failure
- computed tomography
- machine learning
- metabolic syndrome
- artificial intelligence
- quantum dots
- mesenchymal stem cells
- left ventricular