In vitro and in vivo analyses of eFAP: a novel FAP-targeting small molecule for radionuclide theranostics and other oncological interventions.
Circe D van der HeideHanyue MaMark W H HoorensJoana D CampeiroDebra C StuurmanCorrina M A de RidderYann SeimbilleSimone U DalmPublished in: EJNMMI radiopharmacy and chemistry (2024)
The superior affinity and faster tumor accumulation of eFAP-6 over FAPI-46 makes it a suitable compound for radionuclide imaging. After further optimization, the eFAP series has great potential for various oncological interventions, including fluorescent-guided surgery and effective targeted radionuclide theranostics.