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Well-Differentiated Neuroendocrine Tumors of the Appendix in Children and Adolescents: A Clinicopathologic Study.

Caroline T SimonPeter EhrlichAnastasia HryhorczukRaja RabahLaura K SedigTammy StollAmer Heider
Published in: Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society (2023)
Our study showed that all pediatric well-differentiated appendiceal NET were incidentally found as part of acute appendicitis management. Most NET were localized with low-grade histology. Our small cohort support the previously suggested management guidelines with follow up resection in certain cases. Our radiologic review didn't identify a best modality for NET. Comparing cases with and without metastatic disease, no tumors under 1 cm had metastasis, but serosal and perineural invasion along with G2 status were associated with metastasis in our limited study.
Keyphrases
  • low grade
  • high grade
  • squamous cell carcinoma
  • small cell lung cancer
  • clinical practice
  • neuroendocrine tumors