Ocular injuries caused by inflammation, surgery or accidents are subject to a physiological healing process that ultimately restores the structure and function of the damaged tissue. Tryptase and trypsin are essential component of this process and they play a role in promoting and reducing the inflammatory response of tissues, respectively. Following injury, tryptase is endogenously produced by mast cells and can exacerbate the inflammatory response both by stimulating neutrophil secretion, and through its agonist action on proteinase-activated receptor 2 (PAR2). In contrast, exogenously introduced trypsin promotes wound healing by attenuating inflammatory responses, reducing oedema and protecting against infection. Thus, trypsin may help resolve ocular inflammatory symptoms and promote faster recovery from acute tissue injury associated with ophthalmic diseases. This article describes the roles of tryptase and exogenous trypsin in affected tissues after onset of ocular injury, and the clinical applications of trypsin injection.
Keyphrases
- inflammatory response
- oxidative stress
- gene expression
- minimally invasive
- lipopolysaccharide induced
- wound healing
- liver failure
- lps induced
- optic nerve
- toll like receptor
- computed tomography
- physical activity
- intensive care unit
- respiratory failure
- acute respiratory distress syndrome
- coronary artery bypass
- ultrasound guided
- sleep quality
- contrast enhanced