Heterogeneity of PD-L1 expression and CD8 tumor-infiltrating lymphocytes among subtypes of cutaneous adnexal carcinomas.

Lucie DuvergerAmélie OsioBernard CribierLaurent MortierAdèle De MassonNicole Basset-SeguinCéleste LebbéMaxime Battistella

Published in: Cancer immunology, immunotherapy : CII (2019)

PD-L1 expression is highly heterogeneous among adnexal carcinoma subtypes, higher in apocrine carcinoma and invasive extramammary Paget disease, and associated with CD8+ TILs. Our data suggest the interest of evaluating anti-PD1 immunotherapy in advanced or metastatic cutaneous adnexal carcinoma.

Keyphrases

squamous cell carcinoma
small cell lung cancer
high grade
single cell
peripheral blood
nk cells
deep learning