Histiocytic Sarcoma Associated with Coombs Negative Acute Hemolytic Anemia: A Rare Presentation.

Sandeep BatraStephen C MartinMehdi NassiriAmna QureshiTroy A Markel

Published in: Case reports in oncological medicine (2016)

Histiocytic sarcoma (HS) rarely involves extranodal sites, such as the spleen. We report a unique pediatric case of massive splenomegaly and refractory Coombs negative hemolytic anemia (CNHA) secondary to HS. The CNHA resolved completely after an emergent splenectomy. Next generation sequencing (NGS) revealed novel ASXL1, PTPN11, KIT, and TP53 mutations, unmasking a clonal heterogeneity within the same neoplasm.

Keyphrases

iron deficiency
chronic kidney disease
single cell
liver failure
respiratory failure
low grade
drug induced
case report
aortic dissection
intensive care unit
gene expression
circulating tumor
circulating tumor cells