Associations between accelerometer-derived sedentary behavior and physical activity with white matter hyperintensities in middle-aged to older adults.
David A RaichlenMadeline AllyDaniel H AslanM Katherine SayrePradyumna K BharadwajSilvio MaltagliatiMark H C LaiRand R WilcoxChristian G HabeckYann C KlimentidisGene E AlexanderPublished in: Alzheimer's & dementia (Amsterdam, Netherlands) (2024)
SB is associated with greater WMH volumes and MVPA is associated with lower WMH volumes.Relationships between SB and WMH are strongest at low levels of MVPA.Associations between MVPA and WMH are strongest at high levels of SB.Considering both SB and MVPA may be effective strategies for reducing WMHs.