Comparison of the Visibility of Fetal Tooth Buds on 1.5 and 3 Tesla MRI.
Burkhard KunzendorfMariana C DiogoDelfina I CoviniMichael WeberGerlinde M GruberHans-Florian ZeilhoferBritt-Isabelle BergDaniela PrayerPublished in: Journal of clinical medicine (2020)
Dental anomalies coincide with genetic disorders, and prenatal identification may contribute to a more accurate diagnosis. The aim of this study was to assess whether fetal Magnet Resonance Imaging (MRI) is suitable to visualize and investigate intrauterine dental development in the upper jaw, and to compare the quality of visibility of tooth buds between 1.5 Tesla (T) and 3T images. MR images of fetuses Gestational Week (GW) 26.71 ± 4.97 from 286 pregnant women with diagnoses unrelated to dental anomalies were assessed by three raters. We compared the visibility between groups and field strengths in five gestational age groups, using chi square and Fisher's exact tests. All ten primary tooth buds were identifiable in 5.4% at GW 18-21, in 75.5% at GW 26-29, and in 90.6% at GW 34+. Before GW 30, more tooth buds were identifiable on 3T images than on 1.5T images. Statistical significance was only reached for identification of incisors (p = 0.047). Therefore, 1.5T and 3T images are viable to visualize tooth buds, particularly after GW 25, and their analysis may serve as diagnostic criterion. MRI tooth bud data might have an impact on various fields of research, such as the maldevelopment of teeth and their causes. Analyzing tooth buds as an additional diagnostic criterion is not time consuming, and could lead to an improvement of syndrome diagnosis.
Keyphrases
- deep learning
- convolutional neural network
- gestational age
- contrast enhanced
- optical coherence tomography
- magnetic resonance imaging
- pregnant women
- magnetic resonance
- birth weight
- high resolution
- preterm birth
- diffusion weighted imaging
- genome wide
- weight gain
- computed tomography
- mass spectrometry
- electronic health record
- dna methylation
- density functional theory
- data analysis