Value of Artificial Intelligence in Evaluating Lymph Node Metastases.
Nicolò CaldonazziPaola Chiara RizzoAlbino EccherIlaria GirolamiGiuseppe Nicolò FanelliAntonio Giuseppe NaccaratoGiuseppina BonizziNicola FuscoGiulia d'AmatiAldo ScarpaLiron PantanowitzStefano MarlettaPublished in: Cancers (2023)
One of the most relevant prognostic factors in cancer staging is the presence of lymph node (LN) metastasis. Evaluating lymph nodes for the presence of metastatic cancerous cells can be a lengthy, monotonous, and error-prone process. Owing to digital pathology, artificial intelligence (AI) applied to whole slide images (WSIs) of lymph nodes can be exploited for the automatic detection of metastatic tissue. The aim of this study was to review the literature regarding the implementation of AI as a tool for the detection of metastases in LNs in WSIs. A systematic literature search was conducted in PubMed and Embase databases. Studies involving the application of AI techniques to automatically analyze LN status were included. Of 4584 retrieved articles, 23 were included. Relevant articles were labeled into three categories based upon the accuracy of AI in evaluating LNs. Published data overall indicate that the application of AI in detecting LN metastases is promising and can be proficiently employed in daily pathology practice.
Keyphrases
- artificial intelligence
- lymph node
- deep learning
- big data
- machine learning
- prognostic factors
- sentinel lymph node
- neoadjuvant chemotherapy
- squamous cell carcinoma
- systematic review
- primary care
- small cell lung cancer
- healthcare
- convolutional neural network
- induced apoptosis
- loop mediated isothermal amplification
- physical activity
- label free
- electronic health record
- real time pcr
- computed tomography
- cell death
- cell cycle arrest
- young adults
- meta analyses
- case control
- papillary thyroid
- positron emission tomography
- locally advanced