α2A-Adrenoceptors Modulate Renal Sympathetic Neurotransmission and Protect against Hypertensive Kidney Disease.

Lydia HeringMasudur RahmanHenning HochLajos MarkóGuang YangAnnika ReilMina YakoubVikram GuptaSebastian A PotthoffOliver VonendDonna L RalphSusan B GurleyAlicia A McDonoughLars C RumpJohannes Stegbauer

Published in: Journal of the American Society of Nephrology : JASN (2020)

Our findings reveal a protective role of prejunctional inhibitory α2A-adrenoceptors in pathophysiologic conditions with an activated renin-angiotensin system, such as hypertensive kidney disease, and support the concept of sympatholytic therapy as a treatment.

Keyphrases

blood pressure
genome wide
single cell
stem cells
dna methylation
gene expression
cell therapy