Investigation of Bosentan's Effects on Pulmonary Contusion Created by Blunt Thoracic Trauma in Rats.
Gonca GercelBurhan AksuSeyma OzkanliHafize UzunFeyza AksuErdem OzatmanÇiğdem Ulukaya DurakbaşaPublished in: European journal of pediatric surgery : official journal of Austrian Association of Pediatric Surgery ... [et al] = Zeitschrift fur Kinderchirurgie (2019)
PC causes progressive lung tissue damage. Bosentan reduced leukocyte infiltration and alveolar edema and congestion caused by PC. It also decreased MDA levels and increased SOD levels. Bosentan prevents tissue damage by inhibiting acute inflammatory response and reduces oxidative stress secondary to inflammation. It has therapeutic effects on apoptosis.
Keyphrases
- oxidative stress
- pulmonary arterial hypertension
- inflammatory response
- spinal cord
- diabetic rats
- pulmonary hypertension
- dna damage
- ischemia reperfusion injury
- induced apoptosis
- liver failure
- trauma patients
- multiple sclerosis
- lipopolysaccharide induced
- cell cycle arrest
- respiratory failure
- lps induced
- signaling pathway
- drug induced
- breast cancer cells
- toll like receptor
- heat shock
- cell proliferation
- aortic dissection
- pi k akt
- heat shock protein