Super-enhancer-driven IRF2BP2 enhances ALK activity and promotes neuroblastoma cell proliferation.
Yan Ling ChenRan ZhuoLi Chao SunYan Fang TaoGen LiFrank ZhuYun Yun XuJian Wei WangZhi Heng LiJuan Juan YuHong Li YinDi WuXiao Lu LiFang FangYi XieYi Zhou HuHai Rong WangChun YangLei ShiXiao Dong WangZi Mu ZhangJian PanPublished in: Neuro-oncology (2024)
Our findings indicate that SE-driven IRF2BP2 can bind to AP-1 to maintain the survival of tumor cells via regulating chromatin accessibility of NB susceptibility gene ALK.