High-Strength Injectable Hydrogel into Perivascular Interstitial Space Enhances Arterial Adventitial Stress.
Yuting ZhuKai LiQiang ZhangYifeng NieTun YanXiaoli ShiDong HanPublished in: Langmuir : the ACS journal of surfaces and colloids (2023)
Injectable hydrogels with strong mechanical properties have significant potential for biomedical applications, including the development of electronic skin, intelligent medical robots, as well as tissue engineering. In this study, we report on an injectable hydrogel with notable tensile strength and adhesion properties, achieved through cross-linking thiol-terminated four-arm poly (ethylene glycol) using silver-doped nano-hydroxyapatite, modified with dopamine. Subsequently, the hydrogel was injected in vivo through the perivascular interstitial space of rats. The hydrogel wrapped around the damaged abdominal aortic adventitia, which greatly increases the stress strength of the arterial adventitia. We found that the hydrogel was characterized by excellent biocompatibility, and it induced little immune response over a span of 21 days post-implantation. This simple and minimally invasive vascular protection strategy appears promising for the treatment of vascular diseases, such as abdominal aortic aneurysm (AAA).
Keyphrases
- tissue engineering
- abdominal aortic aneurysm
- hyaluronic acid
- immune response
- minimally invasive
- abdominal aortic
- healthcare
- drug delivery
- quantum dots
- gold nanoparticles
- dendritic cells
- stress induced
- pseudomonas aeruginosa
- wound healing
- inflammatory response
- climate change
- toll like receptor
- silver nanoparticles
- risk assessment
- highly efficient
- biofilm formation
- endothelial cells
- combination therapy
- robot assisted