Broad Severe Acute Respiratory Syndrome Coronavirus 2 Cell Tropism and Immunopathology in Lung Tissues From Fatal Coronavirus Disease 2019.

Suzane Ramos da SilvaEnguo JuWen MengAlberto E Paniz MondolfiSanja DacicAnthony GreenClare BryceZachary GrimesMary FowkesEmilia M SordilloCarlos Cordon-CardoHaitao GuoShou-Jiang Gao

Published in: The Journal of infectious diseases (2021)

In fatal COVID-19 lungs, there are broad SARS-CoV-2 cell tropisms, extensive infiltrated innate immune cells, and activation and depletion of adaptive immune cells, contributing to severe tissue damage, thromboemboli, excess inflammation, and compromised immune responses.

Keyphrases

respiratory syndrome coronavirus
sars cov
coronavirus disease
immune response
single cell
cell therapy
oxidative stress
gene expression
early onset
toll like receptor