HOX genes promote cell proliferation and are potential therapeutic targets in adrenocortical tumours.

Jeffrey C FrancisJennifer R GardinerYoan RenaudRitika ChauhanYacob WeinsteinCelso Gomez-SanchezAnne-Marie Lefrançois-MartinezJérôme BertheratPierre ValAmanda Swain

Published in: British journal of cancer (2020)

These studies show Hoxb9 can promote adrenal tumour progression in a sex-dependent manner and have identified HOX factors as potential drug targets, leading to novel therapeutic approaches in ACC.

Keyphrases

cell proliferation
human health
genome wide
cell cycle
emergency department
gene expression
signaling pathway
drug induced