Supporting materials: Endothelial cells differentiated from patient dermal fibroblast-derived induced pluripotent stem cells resemble vascular malformations of Port Wine Birthmark.
Vi NguyenChao GaoMarcelo L HochmanJacob KravitzElliott H ChenHarold I FriedmanCamilla F WenceslauDongbao ChenYunguan WangJ Stuart NelsonAnil G JeggaWenbin TanPublished in: bioRxiv : the preprint server for biology (2023)
Targeting Hippo and Wnt pathways and Zinc-finger family genes could restore the physiological differentiation of ECs.Targeting NF-kappa B, TNF, MAPK, and cholesterol metabolism pathways could mitigate the pathological progression of PWB.These mechanisms may lead to the development of paradigm-shifting therapeutic interventions for PWB.
Keyphrases
- induced pluripotent stem cells
- signaling pathway
- endothelial cells
- nuclear factor
- cancer therapy
- oxidative stress
- pi k akt
- rheumatoid arthritis
- stem cells
- cell proliferation
- genome wide
- case report
- physical activity
- lps induced
- toll like receptor
- wound healing
- robot assisted
- drug delivery
- transcription factor
- low density lipoprotein
- dna methylation
- oxide nanoparticles
- laparoscopic surgery
- bioinformatics analysis