Enhancing CD19 Chimeric Antigen Receptor T Cells Through Memory-Enriched T Cells.

Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2023)

Chimeric antigen receptor T (CAR-T) cells directed against CD19 have transformed the therapy of relapsed/refractory B-cell acute lymphoblastic leukemia (R/R B-ALL). A recent study reports promising activity and safety of CD19 CAR-T cells generated from naïve, stem, and central memory T cells in adults with R/R B-ALL. See related article by Aldoss et al., p. 742.

Keyphrases

acute lymphoblastic leukemia
induced apoptosis
working memory
nk cells
stem cells
allogeneic hematopoietic stem cell transplantation
cell cycle arrest
multiple myeloma
signaling pathway
cell death
endoplasmic reticulum stress
hodgkin lymphoma
pi k akt