Systematic screening reveals synergistic interactions that overcome MAPK inhibitor resistance in cancer cells.

Yu YuMinzhen TaoLibin XuLei CaoBaoyu LeNa AnJilin DongYajie XuBaoxing YangWei LiBing LiuQiong WuYinying LuZhen Xie Xiaohua Lian

Published in: Cancer biology & medicine (2021)

Pair-wise sgRNA library screening provided systematic insights into elucidating MAPKi resistance in cancer cells. ITGB3- + IGF1R-targeting drugs (cilengitide + linsitinib) could be used as an effective therapy for suppressing the adaptive formation of the HDGF-LGR5 protein complex, which enhanced cancer stemness during MAPKi stress.

Keyphrases

signaling pathway
cancer therapy
pi k akt
papillary thyroid
stem cells
epithelial mesenchymal transition
binding protein
oxidative stress
squamous cell
young adults
heat stress
childhood cancer