Gene Variants of the OAS/RNase L Pathway and Their Association with Severity of Symptoms and Outcome of SARS-CoV-2 Infection.
Aurelio Perez-FavilaSonia Sanchez-MaciasSergio A Oropeza De LaraIdalia Garza-VelozRoxana Araujo-EspinoMaria E Castañeda-LopezAlejandro Mauricio-GonzalezSodel Vázquez-ReyesPerla Velasco-ElizondoPerla M Trejo-OrtizFabiana E Mollinedo MontañoClaudia Castruita-De la RosaMargarita L Martinez-FierroPublished in: Journal of personalized medicine (2024)
gene rs2285932 are less likely to develop symptomatic COVID-19, suggesting these genetic variations may confer a protective effect among the Mexican study population. Furthermore, the observed differences in genotype frequencies between asymptomatic individuals and those with severe disease emphasize the potential of these variants as markers for disease severity. These insights enhance our understanding of the genetic factors that may influence the course of COVID-19 and underscore the potential for genetic screening in identifying individuals at increased risk for severe disease outcomes.
Keyphrases
- copy number
- genome wide
- coronavirus disease
- sars cov
- dna methylation
- early onset
- respiratory syndrome coronavirus
- type diabetes
- human health
- depressive symptoms
- physical activity
- metabolic syndrome
- insulin resistance
- genome wide identification
- transcription factor
- climate change
- drug induced
- sleep quality
- glycemic control