Loss of m6A demethylase ALKBH5 alleviates hypoxia-induced pulmonary arterial hypertension via inhibiting Cyp1a1 mRNA decay.

Ning GuYoucheng ShenYuanjie HeChaofu LiWeidong XiongYiqing HuZhimei QiuFengli PengWeiyu HanChaozhong LiXianping LongRanzun ZhaoYongchao ZhaoBei Shi

Published in: Journal of molecular and cellular cardiology (2024)

The current study highlights the loss of Alkbh5 impedes the proliferation and migration of PASMCs by inhibiting post-transcriptional Cyp1a1 mRNA decay in an m6A-dependent manner.

Keyphrases

pulmonary arterial hypertension
pulmonary artery
pulmonary hypertension
signaling pathway
gene expression
binding protein
transcription factor
heat shock protein