Biogenic Phytochemicals Modulating Obesity: From Molecular Mechanism to Preventive and Therapeutic Approaches.
Vikram KumarDesh Deepak SinghSudarshan Singh LakhawatNusrath YasmeenAishwarya PandeyRajeev K SinglaPublished in: Evidence-based complementary and alternative medicine : eCAM (2022)
The incidence of obesity and over bodyweight is emerging as a major health concern. Obesity is a complex metabolic disease with multiple pathophysiological clinical conditions as comorbidities are associated with obesity such as diabetes, hypertension, cardiovascular disorders, sleep apnea, osteoarthritis, some cancers, and inflammation-based clinical conditions. In obese individuals, adipocyte cells increased the expression of leptin, angiotensin, adipocytokines, plasminogen activators, and C-reactive protein. Currently, options for treatment and lifestyle behaviors interventions are limited, and keeping a healthy lifestyle is challenging. Various types of phytochemicals have been investigated for antiobesity potential. Here, we discuss pathophysiology and signaling pathways in obesity, epigenetic regulations, regulatory mechanism, functional ingredients in natural antiobesity products, and therapeutic application of phytochemicals in obesity.
Keyphrases
- weight loss
- metabolic syndrome
- insulin resistance
- type diabetes
- high fat diet induced
- weight gain
- bariatric surgery
- adipose tissue
- cardiovascular disease
- sleep apnea
- signaling pathway
- physical activity
- public health
- blood pressure
- skeletal muscle
- rheumatoid arthritis
- gene expression
- induced apoptosis
- epithelial mesenchymal transition
- young adults
- risk assessment
- body mass index
- cell death
- mass spectrometry
- angiotensin ii
- cell cycle arrest
- obstructive sleep apnea
- obese patients
- pi k akt
- atomic force microscopy
- single molecule