Advanced glycated end-products inhibit dilation through constitutive endothelial RAGE and Nox1/4 in rat isolated skeletal muscle arteries.
Nadim NaserChenchel K LonjMatthew Rikard-BellShaun L SandowTimothy V MurphyPublished in: Microcirculation (New York, N.Y. : 1994) (2023)
These observations suggest RAGE are constitutively expressed in the endothelium of the rat CMA and may be activated by AGE to stimulate Nox1/4 and ROS formation with resulting inhibition of NO and BKCa-mediated endothelium-dependent dilation.