Titanium Alkoxide-Based Regioselective Alkyne-Alkyne Reductive Coupling Mediated by In Situ Generated Arylamidate.

Titanium alkoxide-based alkyne-alkyne reductive coupling mediated by in situ generated arylamidate is described. A high level of regioselectivity is achieved in 37 examples, where (E,E)-dienes are exclusively formed. To the best of our knowledge, this study represents the first example of an apparent amide and carbamate directing effect in metal-mediated reductive coupling.